Use of zebrafish in drug discovery toxicology

S Cassar, I Adatto, JL Freeman, JT Gamse… - Chemical research in …, 2019 - ACS Publications
Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

[HTML][HTML] Zebrafish larvae as a behavioral model in neuropharmacology

RM Basnet, D Zizioli, S Taweedet, D Finazzi, M Memo - Biomedicines, 2019 - mdpi.com
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …

Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond

AV Kalueff, M Gebhardt, AM Stewart, JM Cachat… - Zebrafish, 2013 - liebertpub.com
Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and
behavioral research. Physiological similarity to mammals, ease of genetic manipulations …

[HTML][HTML] Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo

Y Li, X Du, C Liu, Z Wen, J Du - Developmental cell, 2012 - cell.com
Microglia are the primary immune cells in the brain. Under physiological conditions, they
typically stay in a" resting" state, with ramified processes continuously extending to and …

Whole-body cortisol response of zebrafish to acute net handling stress

JM Ramsay, GW Feist, ZM Varga, M Westerfield… - Aquaculture, 2009 - Elsevier
Zebrafish, Danio rerio, are frequently handled during husbandry and experimental
procedures in the laboratory, yet little is known about the physiological responses to such …

[HTML][HTML] Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior

Y Kölsch, J Hahn, A Sappington, M Stemmer… - Neuron, 2021 - cell.com
Retinal ganglion cells (RGCs) form an array of feature detectors, which convey visual
information to central brain regions. Characterizing RGC diversity is required to understand …

Imaging escape and avoidance behavior in zebrafish larvae

RM Colwill, R Creton - 2011 - degruyter.com
This review provides an overview of the assays that are used for measuring escape and
avoidance behavior in zebrafish, with a specific focus on zebrafish larvae during the first …

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery

TP Barros, WK Alderton, HM Reynolds… - British journal of …, 2008 - Wiley Online Library
The zebrafish is a well‐established model organism used in developmental biology. In the
last decade, this technology has been extended to the generation of high‐value knowledge …

[HTML][HTML] Zebrafish—on the move towards ophthalmological research

J Chhetri, G Jacobson, N Gueven - Eye, 2014 - nature.com
Millions of people are affected by visual impairment and blindness globally, and the
prevalence of vision loss is likely to increase as we are living longer. However, many ocular …

Nanopolystyrene particles at environmentally relevant concentrations causes behavioral and biochemical changes in juvenile grass carp (Ctenopharyngodon idella)

ATB Guimarães, FN Estrela… - Journal of Hazardous …, 2021 - Elsevier
The biometric, behavioral and biochemical toxicity of polystyrene nanoplastics (PS NPs) in
aquatic freshwater vertebrates and in environmentally relevant concentrations remains …