Intracellular mRNA transport and localized translation

S Das, M Vera, V Gandin, RH Singer… - Nature reviews Molecular …, 2021 - nature.com
Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Mammalian stress granules and P bodies at a glance

CL Riggs, N Kedersha, P Ivanov… - Journal of cell …, 2020 - journals.biologists.com
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …

[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

[HTML][HTML] Single-molecule imaging reveals translation of mRNAs localized to stress granules

D Mateju, B Eichenberger, F Voigt, J Eglinger, G Roth… - Cell, 2020 - cell.com
Cellular stress leads to reprogramming of mRNA translation and formation of stress granules
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …

A new phase of networking: the molecular composition and regulatory dynamics of mammalian stress granules

SR Millar, JQ Huang, KJ Schreiber, YC Tsai… - Chemical …, 2023 - ACS Publications
Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …

Stressful steps: progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules

H Glauninger, CJW Hickernell, JAM Bard… - Molecular cell, 2022 - cell.com
Stress-induced condensation of mRNA and protein into massive cytosolic clusters is
conserved across eukaryotes. Known as stress granules when visible by imaging, these …

Ribosome pausing, a dangerous necessity for co-translational events

MA Collart, B Weiss - Nucleic acids research, 2020 - academic.oup.com
In recent years translation elongation has emerged as an important contributor to the
regulation of gene expression. There are multiple quality control checkpoints along the way …

[HTML][HTML] Liquid–liquid phase separation in autophagy

NN Noda, Z Wang, H Zhang - Journal of Cell Biology, 2020 - rupress.org
Liquid–liquid phase separation (LLPS) compartmentalizes and concentrates
biomacromolecules into distinct condensates. Liquid-like condensates can transition into gel …

Y-box binding proteins in mRNP assembly, translation, and stability control

D Mordovkina, DN Lyabin, EA Smolin, EM Sogorina… - Biomolecules, 2020 - mdpi.com
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …

Ribosome and translational control in stem cells

M Gabut, F Bourdelais, S Durand - Cells, 2020 - mdpi.com
Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …