Intracellular mRNA transport and localized translation
Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …
precise temporal and spatial control of gene expression. High-resolution imaging …
Mammalian stress granules and P bodies at a glance
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …
based cellular compartments that assemble in response to stress. SGs and PBs form …
[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly
S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
compartments that form in the cytoplasm of a cell upon exposure to various environmental …
[HTML][HTML] Single-molecule imaging reveals translation of mRNAs localized to stress granules
Cellular stress leads to reprogramming of mRNA translation and formation of stress granules
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …
(SGs), membraneless organelles consisting of mRNA and RNA-binding proteins. Although …
A new phase of networking: the molecular composition and regulatory dynamics of mammalian stress granules
SR Millar, JQ Huang, KJ Schreiber, YC Tsai… - Chemical …, 2023 - ACS Publications
Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …
Stressful steps: progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules
H Glauninger, CJW Hickernell, JAM Bard… - Molecular cell, 2022 - cell.com
Stress-induced condensation of mRNA and protein into massive cytosolic clusters is
conserved across eukaryotes. Known as stress granules when visible by imaging, these …
conserved across eukaryotes. Known as stress granules when visible by imaging, these …
Ribosome pausing, a dangerous necessity for co-translational events
MA Collart, B Weiss - Nucleic acids research, 2020 - academic.oup.com
In recent years translation elongation has emerged as an important contributor to the
regulation of gene expression. There are multiple quality control checkpoints along the way …
regulation of gene expression. There are multiple quality control checkpoints along the way …
[HTML][HTML] Liquid–liquid phase separation in autophagy
Liquid–liquid phase separation (LLPS) compartmentalizes and concentrates
biomacromolecules into distinct condensates. Liquid-like condensates can transition into gel …
biomacromolecules into distinct condensates. Liquid-like condensates can transition into gel …
Y-box binding proteins in mRNP assembly, translation, and stability control
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …
family of proteins with the cold shock domain. Functionally, these proteins are known to be …
Ribosome and translational control in stem cells
M Gabut, F Bourdelais, S Durand - Cells, 2020 - mdpi.com
Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …
to self-renew while remaining poised to differentiate into multiple progenies in the context of …