Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an
endopeptidase activity. Although its primary functions were originally thought to be only of a …

Cathepsin L (CatL) is a lysosomal cysteine protease whose activity has been related to
several human pathologies. However, although preclinical trials using CatL inhibitors were …

The cysteine protease cathepsin K is a target for the treatment of diseases associated with
high bone turnover. Cathepsin K is mainly expressed in osteoclasts and responsible for the …

Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell
invasion and migration through degradation of the extracellular matrix suggest that …

A series of inhibitors targeting human cathepsins have been designed and synthesized
following a combinatorial approach. The compounds bear an α, β-unsaturated phenyl vinyl …

Human cathepsin L is a ubiquitously expressed endopeptidase and is known to play critical
roles in a wide variety of cellular signaling events. Its overexpression has been implicated in …

abstract HLA-DR is the most commonly expressed and likely the most medically important
human MHC class II, antigen presenting protein. In a normal immune response, HLA-DR …

Human cathepsin L inhibitors and probes containing a vinyl sulfonate ester moiety are
described. The inhibitors are highly potent (low nM affinity), selective, and cell perme able …

Mestastasis is a devastating component associated with tumor progression which claims the
majority of lives lost to cancer. Upregulation of cathepsin L, a powerful cysteine protease …

The present thesis elucidates the development of (i) a series of small molecule inhibitors
reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently …