Dopamine is a major neurotransmitter in the central nervous system. Receptors for this
catecholamine are of considerable interest, as they are the principal target of drugs …

The cDNA for the dopamine D3 receptor was isolated and characterized in 1990.
Subsequent studies have indicated that D3 receptors, as well as D3 receptor mRNA, are …

Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in
the mediation of cost/benefit evaluations about delay or effort-related costs associated with …

Previous research has identified the nucleus accumbens (NAcb) as an important brain
region underlying inter-individual variation in impulsive behavior. Such variation has been …

Rationale Deficient response inhibition is a prominent feature of many pathological
conditions characterised by impulsive and compulsive behaviour. Clinically effective doses …

Behavioral sensitization is a progressive, enduring enhancement of behaviors that develops
following repeated stimulant administration. It is mediated in part by dopaminergic pathways …

Rationale Dopamine is strongly implicated in the ability to shift behavior in response to
changing stimulus-reward contingencies. Objectives We investigated the effects of systemic …

Dopamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology
Database Page 1 IUPHAR/BPS Guide to Pharmacology CITE https://doi.org/10.2218/gtopdb/F20/2019.4 …

“Evolution consists largely of molecular tinkering.”—Following the famous concept of the
molecular geneticist and medicine Nobel laureate François Jacob, in this review we …

The D 3 dopamine receptor is a member of the family of D 2-like dopamine receptors. Since
the cloning and identification of the D 3 receptor in 1990, considerable progress has been …