Background The association between obesity and fracture risk may be skeletal site-and sex-
specific but results among studies are inconsistent. Whilst several studies reported higher …

So far, the connections between obesity and skeleton have been extensively explored, but
the results are inconsistent. Obesity is thought to affect bone health through a variety of …

Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a
result of our aging society, high caloric intake and sedentary lifestyle. Besides the well …

Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown
adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose …

Adipose tissue is a dynamic component of the bone marrow, regulating skeletal remodelling
and secreting paracrine and endocrine factors that can affect haematopoiesis, as well as …

Because of heavy energy demands to maintain bone homeostasis, the skeletal system is
closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose …

In recent years, adipose tissue has attracted a lot of attention. It is not only an energy
reservoir but also plays important immune, paracrine and endocrine roles. BMAT (bone …

Bone marrow adipocytes (BMA-) constitute an original and heterogeneous fat depot whose
development appears interlinked with bone status throughout life. The gradual replacement …

Biological processes utilize energy and therefore must be prioritized based on fuel
availability. Bone is no exception to this, and the benefit of remodeling when necessary …