Myeloperoxidase (MPO) is a heme-containing peroxidase expressed mainly in neutrophils
and to a lesser degree in monocytes. In the presence of hydrogen peroxide and halides …

Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly
expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

This review discusses the formation of hypochlorous acid HOCl and the role of reactive
chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO …

The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …

The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli.
p38 function has been studied in depth in relation to cardiac development and function. The …

Myocardial infarction (MI) is one of the most common cardiac emergencies with high
morbidity and is a leading cause of death worldwide. Since MI could develop into a life …

Inflammation is a well‐known feature of heart failure. Studies have shown that while some
inflammation is required for repair during injury and is protective, prolonged inflammation …

Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac
inflammation that leads to infarct expansion and heart failure (HF). We previously showed …

Cells sense mechanical stress and changes in their matrix environment through the
integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands …