In the past two decades, record-breaking heatwaves have caused an increasing number of
heat-related deaths, including heatstroke, globally. Heatstroke is a heat illness characterized …

The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Heat-shock transcription factor 1 (HSF1) orchestrates the fast and vast cellular response to
heat shock through increased expression of heat-shock proteins. However, how HSF1 …

We provide a protocol for precision nuclear run-on sequencing (PRO-seq) and its variant,
PRO-cap, which map the location of active RNA polymerases (PRO-seq) or transcription …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …

The increased prevalence of high temperatures (HTs) around the world is a major global
concern, as they dramatically affect agronomic productivity. Upon HT exposure, plants sense …

Conserved families of molecular chaperones assist protein folding in the cell. Here we
review the conceptual advances on three major folding routes:(i) spontaneous, chaperone …

The heat shock response (HSR) was originally discovered as a transcriptional response to
elevated temperature shock and led to the identification of heat shock proteins and heat …

Proteotoxic stress, that is, stress caused by protein misfolding and aggregation, triggers the
rapid and global reprogramming of transcription at genes and enhancers. Genome-wide …