It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …

Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of
peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus …

Alzheimer's disease (AD) progressively inflicts impairment of synaptic functions with notable
deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain …

Neurodegenerative disorders are one of the most common causes of disability and
represent 6.3% of the global burden of disease. Among them, Alzheimer's, Parkinson's, and …

Neurodegenerative diseases are a major burden for our society, affecting millions of people
worldwide. A main goal of past and current research is to enhance our understanding of the …

We previously reported that Herpes simplex virus type-1 (HSV-1) infection of cultured
neurons triggered intracellular accumulation of amyloid-β protein (Aβ) markedly impinging …

Failure of anti-amyloid-β peptide (Aβ) therapies against Alzheimer's disease (AD), a
neurodegenerative disorder characterized by high amounts of the peptide in the brain …

All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both
natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors …

Objective The objectives of this study were to investigate whether the plasma levels of
oligomeric amyloid-β (OAβ) were affected in Alzheimer's disease (AD) and to examine the …

The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …