Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …

Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

Methyl groups are well understood to play a critical role in pharmaceutical molecules,
especially those bearing saturated heterocyclic cores. Accordingly, methods that install …

Sulfoximines have been largely disregarded in medicinal chemistry for a long time.
However, recently, they have risen to the apparent level of stardom on the drug discovery …

The concept of functional groups (FGs), sets of connected atoms that can determine the
intrinsic reactivity of the parent molecule and in part are responsible for the overall …

In recent years, interest in sulfoximine chemistry has been greatly increased. For example, at
least three sulfoximine containing drugs BAY 1143572, BAY 1251152 and AZD6738 have …

DNA damage response (DDR) pathway prevents high level endogenous and environmental
DNA damage being replicated and passed on to the next generation of cells via an …

Recent years have seen a marked increase in the occurrence of sulfoximines in the
chemical sciences, often presented as valuable motifs for medicinal chemistry. This has …

Direct construction of chiral S (VI) from prochiral S (II) is a formidable challenge due to the
inevitable formation of stable chiral S (IV). Previous synthetic strategies rely on the …

The design of bioisosteres represents a creative and productive approach to improve a
molecule, including by enhancing potency, addressing pharmacokinetic challenges …