Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant
roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

In recent years, there has been an increase in knowledge of cancer, accompanied by a
technological development that gives rise to medical oncology. An instrument that allows the …

Epithelial–mesenchymal transition (EMT) is a reversible cellular process, characterized by
changes in gene expression and activation of proteins, favoring the trans-differentiation of …

Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …

Simple Summary Breast cancer (BC) is the most common cancer diagnosed among women
worldwide. Despite numerous studies, the pathogenesis of BC is still poorly understood, and …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Epithelial mesenchymal transition (EMT) is a process comprising cellular and molecular
events which result in cells shifting from an epithelial to a mesenchymal phenotype …

As a member of the TRIM (tripartite motif) protein family, TRIM56 can function as an E3
ubiquitin ligase. In addition, TRIM56 has been shown to possess deubiquitinase activity and …

Prostate cancer is the second most frequently diagnosed cancer among men worldwide,
with the estimated sixth leading cause of cancer death. Despite major advancements in …