Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …

Stimulation of death receptors by agonists such as FasL and TNFα activates apoptotic cell
death in apoptotic-competent conditions or a type of necrotic cell death dependent on RIP1 …

Poly (ADP-ribosylation) is a post-translational modification of proteins playing a crucial role
in many processes, including DNA repair and cell death. The best known poly (ADP …

Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair,
recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced …

Poly (ADP-ribosyl) ation is an important mechanism for the maintenance of genomic integrity
in response to DNA damage. The enzyme responsible for poly (ADP-ribose) synthesis, poly …

Introduction 3. NAD+ and NADH metabolism in cells 3.1. General information about NAD+
and NADH 3.2. NAD+ and NADH synthesis 3.3. NAD+ and NADH catabolism 4. NAD+ and …

Until recently, necrosis, unlike apoptosis, was considered as passive and unregulated form
of cell death. However, during the last decade a number of experimental data demonstrated …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays the active role of “nick sensor” during DNA
repair and apoptosis, when it synthesizes ADP-ribose from NAD+ in the presence of DNA …

According to the classical view, the cytoprotective effect of inhibitors of poly (ADP-ribose)
polymerase (PARP) in oxidative stress was based on the prevention of NAD+ and ATP …