Diversity, application, and synthetic biology of industrially important Aspergillus fungi
The filamentous fungal genus Aspergillus consists of over 340 officially recognized species.
A handful of these Aspergillus fungi are predominantly used for food fermentation and large …
A handful of these Aspergillus fungi are predominantly used for food fermentation and large …
Aspergillus fumigatus and aspergillosis: From basics to clinics
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …
causing numerous invasive infections and a notable mortality in humans, especially in …
Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus
C Zhang, X Meng, X Wei, L Lu - Fungal Genetics and Biology, 2016 - Elsevier
Filamentous fungi have a dominant nonhomologous-end joining (NHEJ) DNA repair
pathway, which results in the majority of transformed progenies having random …
pathway, which results in the majority of transformed progenies having random …
Development of the CRISPR/Cas9 system for targeted gene disruption in Aspergillus fumigatus
Low rates of homologous recombination have broadly encumbered genetic studies in the
fungal pathogen Aspergillus fumigatus. The CRISPR/Cas9 system of bacteria has recently …
fungal pathogen Aspergillus fumigatus. The CRISPR/Cas9 system of bacteria has recently …
Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System
FN Gravelat, A Beauvais, H Liu, MJ Lee… - PLoS …, 2013 - journals.plos.org
Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The
mechanisms underlying the adherence of this mold to host cells and macromolecules have …
mechanisms underlying the adherence of this mold to host cells and macromolecules have …
The fungal exopolysaccharide galactosaminogalactan mediates virulence by enhancing resistance to neutrophil extracellular traps
Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of
invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an …
invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an …
Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death
Humans inhale mold conidia daily and typically experience lifelong asymptomatic
clearance. Conidial germination into tissue-invasive hyphae can occur in individuals with …
clearance. Conidial germination into tissue-invasive hyphae can occur in individuals with …
Deacetylation of fungal exopolysaccharide mediates adhesion and biofilm formation
The mold Aspergillus fumigatus causes invasive infection in immunocompromised patients.
Recently, galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and …
Recently, galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and …
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation
NC Bamford, F Le Mauff, JC Van Loon… - Nature …, 2020 - nature.com
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the
fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase …
fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase …
Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall …
MJ Lee, FN Gravelat, RP Cerone, SD Baptista… - Journal of Biological …, 2014 - ASBMB
The cell wall of Aspergillus fumigatus contains two galactose-containing polysaccharides,
galactomannan and galactosaminogalactan, whose biosynthetic pathways are not well …
galactomannan and galactosaminogalactan, whose biosynthetic pathways are not well …