Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …

With the introduction of multiple new agents, the role of immunotherapy is rapidly expanding
across all malignancies. Bladder cancer is known to be immunogenic and is responsive to …

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of
immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg …

Our current understanding of human tumor-resident myeloid cells is, for the most part, based
on a large body of work in murine models or studies enumerating myeloid cells in patient …

One of the hallmarks of cancer‐related inflammation is the recruitment of monocyte‐
macrophage lineage cells to the tumor microenvironment. These tumor infiltrating myeloid …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …

Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

Hypoxia, ie, oxygen deficiency condition, is one of the most important factors promoting the
growth of tumors. Since its effect on the chemokine system is crucial in understanding the …