Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory
component is present also in the microenvironment of tumours that are not epidemiologically …

Allosteric interactions play vital roles in metabolic processes and signal transduction and,
more recently, have become the focus of numerous pharmacological studies because of the …

The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding
chemokine receptor CXCR4. Here, we show that AMD3100 also binds to the alternative …

G-protein–coupled receptors (GPCRs) are key signaling molecules and are intensely
studied. Whereas GPCRs recognizing small-molecules have been successfully targeted for …

Chemoattractant cytokines or chemokines constitute a family of structurally related proteins
found in vertebrates, bacteria, or viruses. So far, 48 chemokine genes have been identified …

Importance of the field: Chemokines have principally been associated with inflammation due
to their role in the control of leukocyte migration, but just over a decade ago chemokine …

Chronic pain resulting from inflammatory and neuropathic disorders causes considerable
economic and social burden. Pharmacological therapies currently available for certain types …

Once considered a pharmacological curiosity, allosteric modulation of seven
transmembrane domain G-protein-coupled receptors (GPCRs) has emerged as a potentially …

Allosteric receptor ligands bind to a recognition site that is distinct from the binding site of the
endogenous messenger molecule. As a consequence, allosteric agents may attach to …

A major role for human (h) CXCL8 (interleukin-8) in the pathobiology of myelofibrosis (MF)
has been suggested by observations indicating that MF megakaryocytes express increased …