Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are three
endogenously produced gases with important functions in the vasculature, immune defense …

Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …

Background The aberrant expression of phosphofructokinase-platelet (PFKP) plays a crucial
role in the development of various human cancers by modifying diverse biological functions …

Defective β-catenin signaling is accompanied with compensatory neurogenesis process that
may pave to anxiety. β-Catenin has a distinct role in alleviating anxiety in adolescence; …

Esophageal cancer is one of the most common malignant tumors, and the 5-year overall
survival rate is only 20%. Esophageal squamous cell carcinoma (ESCC) is the primary …

Cancer and cardiovascular disease (CVD) are the two biggest killers worldwide. Specific
treatments have been developed for the two diseases. However, mutual therapeutic targets …

Chronic hepatitis B virus (HBV) infection is one of the leading causes of hepatocellular
carcinoma (HCC). The HBV genome is prone to mutate and several variants are closely …

β-Amyloid peptide (Aβ) deposition in the brain is an important pathological change in
Alzheimer's disease (AD). Insulin-degrading enzyme (IDE), which is regulated …

Bacillus anthracis causes anthrax through a combination of bacterial infection and toxemia.
As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent …

Increasing dietary fiber consumption is linked to lower colon cancer incidence, and this
anticancer effect is tied to elevated levels of short-chain fatty acids (eg, butyrate) because of …