[HTML][HTML] Harnessing the Power of Enteric Glial Cells' Plasticity and Multipotency for Advancing Regenerative Medicine

MA Lefèvre, R Soret, N Pilon - International Journal of Molecular Sciences, 2023 - mdpi.com
The enteric nervous system (ENS), known as the intrinsic nervous system of the
gastrointestinal tract, is composed of a diverse array of neuronal and glial cell subtypes …

Mini-review:“ENTERIC GLIA FUNCTIONS IN NERVOUS TISSUE REPAIR: THERAPEUTIC TARGET OR TOOL?”

M Sunardi, C Cirillo - Neuroscience Letters, 2023 - Elsevier
In the body, nerve tissue is not only present in the central nervous system, but also in the
periphery. The enteric nervous system (ENS) is a highly organized intrinsic network of …

[HTML][HTML] Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice

R Hotta, A Rahman, S Bhave, R Stavely, W Pan… - Stem Cell Research & …, 2023 - Springer
Background Enteric neuropathies, which result from abnormalities of the enteric nervous
system, are associated with significant morbidity and high health-care costs, but current …

[HTML][HTML] Optogenetic activation of cholinergic enteric neurons reduces inflammation in experimental colitis

AA Rahman, R Stavely, W Pan, L Ott, K Ohishi… - Cellular and Molecular …, 2024 - Elsevier
Background & Aims Intestinal inflammation is associated with loss of enteric cholinergic
neurons. Given the systemic anti-inflammatory role of cholinergic innervation, we …

[HTML][HTML] Autologous cell transplantation for treatment of colorectal aganglionosis in mice

W Pan, AA Rahman, T Ohkura, R Stavely… - Nature …, 2024 - nature.com
Neurointestinal diseases cause significant morbidity and effective treatments are lacking.
This study aimes to test the feasibility of transplanting autologous enteric neural stem cells …

[HTML][HTML] Essential Role of BMP4 Signaling in the Avian Ceca in Colorectal Enteric Nervous System Development

T Kovács, V Halasy, C Pethő, E Szőcs, Á Soós… - International Journal of …, 2023 - mdpi.com
The enteric nervous system (ENS) is principally derived from vagal neural crest cells that
migrate caudally along the entire length of the gastrointestinal tract, giving rise to neurons …

Isolation, Expansion, and Endoscopic Delivery of Autologous Enteric Neuronal Stem Cells in Swine

R Hotta, W Pan, S Bhave, N Nagy… - Cell …, 2023 - journals.sagepub.com
The enteric nervous system (ENS) is an extensive network of neurons and glia within the
wall of the gastrointestinal (GI) tract that regulates many essential GI functions …

[HTML][HTML] Gut microbiota and parkinson's disease

LR Dominguez Huarcaya… - Cellular, Molecular …, 2021 - cmbr-journal.com
It is possible for the non-motor symptoms (NMS) of Parkinson's disease (PD), which include
constipation, sleep difficulties, and olfactory impairments, to appear up to 20 years before …

[HTML][HTML] Bone marrow stem cells derived from nerves have neurogenic properties and potential utility for regenerative therapy

LC Ott, CY Han, JL Mueller, AA Rahman… - International journal of …, 2023 - mdpi.com
Neurons and glia of the peripheral nervous system are derived from progenitor cell
populations, originating from embryonic neural crest. The neural crest and vasculature are …

[HTML][HTML] Updates and Challenges in ENS Cell Therapy for the Treatment of Neurointestinal Diseases

T Ohkura, AJ Burns, R Hotta - Biomolecules, 2024 - mdpi.com
Neurointestinal diseases represent a significant challenge in clinical management with
current palliative approaches failing to overcome disease and treatment-related morbidity …