The SLC22 family with transporters of organic cations, anions and zwitterions
H Koepsell - Molecular aspects of medicine, 2013 - Elsevier
The SLC22 family contains 13 functionally characterized human plasma membrane proteins
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
each with 12 predicted α-helical transmembrane domains. The family comprises organic …
Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics
A Yonezawa, K Inui - British journal of pharmacology, 2011 - Wiley Online Library
The renal organic cation transport system mediates the tubular secretion of cationic
compounds including drugs, toxins and endogenous metabolites into urine. It consists of a …
compounds including drugs, toxins and endogenous metabolites into urine. It consists of a …
Disease‐associated changes in drug transporters may impact the pharmacokinetics and/or toxicity of drugs: a white paper from the International Transporter …
R Evers, M Piquette‐Miller, JW Polli… - Clinical …, 2018 - Wiley Online Library
Drug transporters are critically important for the absorption, distribution, metabolism, and
excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of …
excretion (ADME) of many drugs and endogenous compounds. Therefore, disruption of …
Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement
QH Hu, C Wang, JM Li, DM Zhang… - American Journal of …, 2009 - journals.physiology.org
Fructose consumption has been recently related to an epidemic of metabolic syndrome, and
hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome. Fructose …
hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome. Fructose …
Identification and quantitative assessment of uremic solutes as inhibitors of renal organic anion transporters, OAT1 and OAT3
One of the characteristics of chronic kidney disease (CKD) is the accumulation of uremic
solutes in the plasma. Less is known about the effects of uremic solutes on transporters that …
solutes in the plasma. Less is known about the effects of uremic solutes on transporters that …
Drug transporters in the kidney: perspectives on species differences, disease status, and molecular docking
W Zou, B Shi, T Zeng, Y Zhang, B Huang… - Frontiers in …, 2021 - frontiersin.org
The kidneys are a pair of important organs that excretes endogenous waste and exogenous
biological agents from the body. Numerous transporters are involved in the excretion …
biological agents from the body. Numerous transporters are involved in the excretion …
Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic …
M Murray, F Zhou - British journal of pharmacology, 2017 - Wiley Online Library
Organic anion transporters (OATs) and organic anion‐transporting polypeptides (OATPs),
encoded by a number of solute carrier (SLC) 22A and SLC organic anion (SLCO) genes …
encoded by a number of solute carrier (SLC) 22A and SLC organic anion (SLCO) genes …
Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications
H Saito - Pharmacology & therapeutics, 2010 - Elsevier
The kidneys play a primary role in maintaining homeostasis and detoxification of diverse
hydrophilic xenobiotics as well as endogenous by-products. Solute carrier (SLC) 22A …
hydrophilic xenobiotics as well as endogenous by-products. Solute carrier (SLC) 22A …
Tubular transport in acute kidney injury: relevance for diagnosis, prognosis and intervention
V Vallon - Nephron, 2016 - karger.com
The clinical diagnosis and recovery of acute kidney injury (AKI) are mainly based on the
rapid decline of glomerular filtration rate (GFR) and its subsequent recovery. The factors that …
rapid decline of glomerular filtration rate (GFR) and its subsequent recovery. The factors that …
Effects of ischemia-reperfusion on tubular cell membrane transporters and consequences in kidney transplantation
Q Faucher, H Alarcan, P Marquet… - Journal of Clinical …, 2020 - mdpi.com
Ischemia-reperfusion (IR)-induced acute kidney injury (IRI) is an inevitable event in kidney
transplantation. It is a complex pathophysiological process associated with numerous …
transplantation. It is a complex pathophysiological process associated with numerous …