[HTML][HTML] IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity
M Gómez-Herranz, J Taylor, RD Sloan - Journal of Biological Chemistry, 2023 - ASBMB
Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …
[HTML][HTML] IFITM protein regulation and functions: Far beyond the fight against viruses
N Friedlová, F Zavadil Kokáš, TR Hupp… - Frontiers in …, 2022 - frontiersin.org
Interferons (IFNs) are important cytokines that regulate immune responses through the
activation of hundreds of genes, including interferon-induced transmembrane proteins …
activation of hundreds of genes, including interferon-induced transmembrane proteins …
[HTML][HTML] The impacts of cholesterol, oxysterols, and cholesterol lowering dietary compounds on the immune system
R Yanagisawa, C He, A Asai, M Hellwig… - International Journal of …, 2022 - mdpi.com
Cholesterol and its oxidized forms, oxysterols, are ingested from foods and are synthesized
de novo. Cholesterol and oxysterols influence molecular and cellular events and …
de novo. Cholesterol and oxysterols influence molecular and cellular events and …
The integral membrane protein ZMPSTE24 protects cells from SARS-CoV-2 spike-mediated pseudovirus infection and syncytia formation
K Shilagardi, ED Spear, R Abraham, DE Griffin… - MBio, 2022 - Am Soc Microbiol
ABSTRACT COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) has had a devastating impact on global public health, emphasizing the …
2 (SARS-CoV-2) has had a devastating impact on global public health, emphasizing the …
[HTML][HTML] 25-hydroxycholesterol: an integrator of antiviral ability and signaling
J Zhang, Y Zhu, X Wang, J Wang - Frontiers in Immunology, 2023 - frontiersin.org
Cholesterol, as an important component in mammalian cells, is efficient for viral entry,
replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized …
replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized …
[HTML][HTML] Gene expression profiling of host lipid metabolism in SARS-CoV-2 infected patients: a systematic review and integrated bioinformatics analysis
Abstract Background The Coronavirus disease 2019 (COVID-19) pandemic occurred due to
the dispersion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe …
the dispersion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe …
[HTML][HTML] IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters
Human interferon-induced transmembrane (IFITM) proteins inhibit the fusion of a broad
spectrum of enveloped viruses, both when expressed in target cells and when present in …
spectrum of enveloped viruses, both when expressed in target cells and when present in …
The 'dispanins' and related proteins in physiology and neurological disease
The dispanins are a family of 15 transmembrane proteins that have diverse and often
unclear physiological functions. Many dispanins, including synapse differentiation induced …
unclear physiological functions. Many dispanins, including synapse differentiation induced …
[HTML][HTML] Does IFITM3 link inflammation to tumorigenesis?
J Lee - BMB reports, 2022 - ncbi.nlm.nih.gov
Uncontrolled chronic inflammation, in most cases due to excessive cytokine signaling
through their receptors, is known to contribute to the development of tumorigenesis …
through their receptors, is known to contribute to the development of tumorigenesis …
[HTML][HTML] The Antiviral Activity of Interferon-Induced Transmembrane Proteins and Virus Evasion Strategies
Interferons (IFNs) are antiviral cytokines that defend against viral infections by inducing the
expression of interferon-stimulated genes (ISGs). Interferon-inducible transmembrane …
expression of interferon-stimulated genes (ISGs). Interferon-inducible transmembrane …