Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …
the mechanisms of which remain largely elusive. Recently, integration of technological …
Human neuronal maturation comes of age: cellular mechanisms and species differences
JL Wallace, AA Pollen - Nature Reviews Neuroscience, 2024 - nature.com
The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …
neurons from other species, may contribute to human-specific cognitive abilities and …
Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
[HTML][HTML] Protracted neuronal recruitment in the temporal lobes of young children
MA Nascimento, S Biagiotti, V Herranz-Pérez… - Nature, 2024 - nature.com
The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the
brain is a highly interconnected integrative hub for sensory and spatial information; it also …
brain is a highly interconnected integrative hub for sensory and spatial information; it also …
Massively parallel characterization of regulatory elements in the developing human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and diseases. Using massively parallel reporter assays in primary human cells …
development and diseases. Using massively parallel reporter assays in primary human cells …
[HTML][HTML] Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and disease. Using massively parallel reporter assays in primary human cells …
development and disease. Using massively parallel reporter assays in primary human cells …
In silico discovery of repetitive elements as key sequence determinants of 3D genome folding
Natural and experimental genetic variants can modify DNA loops and insulating boundaries
to tune transcription, but it is unknown how sequence perturbations affect chromatin …
to tune transcription, but it is unknown how sequence perturbations affect chromatin …
Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements
Most genetic variants associated with psychiatric disorders are located in noncoding regions
of the genome. To investigate their functional implications, we integrate epigenetic data from …
of the genome. To investigate their functional implications, we integrate epigenetic data from …
A molecular and cellular perspective on human brain evolution and tempo
The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …
cellular specializations, which underpin our diverse cognitive abilities but also increase our …
[HTML][HTML] Rare variation in noncoding regions with evolutionary signatures contributes to autism spectrum disorder risk
Little is known about the role of noncoding regions in the etiology of autism spectrum
disorder (ASD). We examined three classes of noncoding regions: Human Accelerated …
disorder (ASD). We examined three classes of noncoding regions: Human Accelerated …