Phosphorylated tau in Alzheimer's disease and other tauopathies

P Rawat, U Sehar, J Bisht, A Selman… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

New insights into the pathogenesis of Alzheimer's disease

L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Synaptic impairment in Alzheimer's disease: a dysregulated symphony

S Forner, D Baglietto-Vargas, AC Martini… - Trends in …, 2017 - cell.com
Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …

Tau-based therapies in neurodegeneration: opportunities and challenges

C Li, J Götz - Nature Reviews Drug Discovery, 2017 - nature.com
Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

[HTML][HTML] Small molecule therapeutics for tauopathy in Alzheimer's disease: walking on the path of most resistance

L Wang, R Kumar, PF Pavlov, B Winblad - European journal of medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia characterized by presence
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …

Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease

A Strom, L Iaccarino, L Edwards, OH Lesman-Segev… - Brain, 2022 - academic.oup.com
Posterior cortical hypometabolism measured with 18F-fluorodeoxyglucose (FDG)-PET is a
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …

[HTML][HTML] Synapses in neurodegenerative diseases

JR Bae, SH Kim - BMB reports, 2017 - ncbi.nlm.nih.gov
Synapse is the basic structural and functional component for neural communication in the
brain. The presynaptic terminal is the structural and functionally essential area that initiates …

The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer's disease

MJ Jembrek, N Slade, PR Hof, G Šimić - Progress in neurobiology, 2018 - Elsevier
Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …

TREM2 and microglia contribute to the synaptic plasticity: from physiology to pathology

CJ Yu, M Wang, RY Li, T Wei, HC Yang, YS Yin… - Molecular …, 2023 - Springer
Synapses are bridges for information transmission in the central nervous system (CNS), and
synaptic plasticity is fundamental for the normal function of synapses, contributing …