Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
Tau-targeting therapies for Alzheimer disease
EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …
New insights into the pathogenesis of Alzheimer's disease
L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …
Synaptic impairment in Alzheimer's disease: a dysregulated symphony
Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …
Tau-based therapies in neurodegeneration: opportunities and challenges
C Li, J Götz - Nature Reviews Drug Discovery, 2017 - nature.com
Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …
[HTML][HTML] Small molecule therapeutics for tauopathy in Alzheimer's disease: walking on the path of most resistance
Alzheimer's disease (AD) is the most common form of dementia characterized by presence
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …
of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau …
Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease
Posterior cortical hypometabolism measured with 18F-fluorodeoxyglucose (FDG)-PET is a
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
[HTML][HTML] Synapses in neurodegenerative diseases
JR Bae, SH Kim - BMB reports, 2017 - ncbi.nlm.nih.gov
Synapse is the basic structural and functional component for neural communication in the
brain. The presynaptic terminal is the structural and functionally essential area that initiates …
brain. The presynaptic terminal is the structural and functionally essential area that initiates …
The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer's disease
Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …
disorder, is characterized by severe cognitive decline and personality changes as a result of …
TREM2 and microglia contribute to the synaptic plasticity: from physiology to pathology
CJ Yu, M Wang, RY Li, T Wei, HC Yang, YS Yin… - Molecular …, 2023 - Springer
Synapses are bridges for information transmission in the central nervous system (CNS), and
synaptic plasticity is fundamental for the normal function of synapses, contributing …
synaptic plasticity is fundamental for the normal function of synapses, contributing …