Mycobacterium tuberculosis is known to synthesize α-, methoxy-, and keto-mycolic acids.
We propose a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis …

M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis
epidemic control. Mechanisms of resistance, including genetic changes favored by selection …

A variety of clustering algorithms have recently been proposed to handle data that is not
linearly separable; spectral clustering and kernel k-means are two of the main methods. In …

The developing science called structural genomics has focused to date mainly on high-
throughput expression of individual proteins, followed by their purification and structure …

Several genetic and epigenetic factors, both in the cell and in the host, contribute to the
progression of tumors towards metastases. The escape of cancer cells from a primary …

Motivation: Determining protein function is one of the most important problems in the post-
genomic era. For the typical proteome, there are no functional annotations for one-third or …

Background Tuberculosis still remains one of the largest killer infectious diseases,
warranting the identification of newer targets and drugs. Identification and validation of …

Although tuberculosis remains a substantial global threat, the mechanisms that enable
mycobacterial persistence and replication within the human host are ill defined. This study …

Structural genomics has brought us three-dimensional structures of proteins with unknown
functions. To shed light on such structures, we have developed ProKnow (http://www. doe …

The bacterial divisome is a multiprotein complex. Specific protein-protein interactions specify
whether cell division occurs optimally, or whether division is arrested. Little is known about …