The approval of venetoclax, a 'BH3-mimetic'antagonist of the BCL-2 anti-apoptotic protein,
for chronic lymphocytic leukemia represents a major milestone in translational apoptosis …

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK) and is
mainly expressed in hematopoietic cells. Syk was recognized as a critical element in the B …

Несмотря на большие успехи в диагностике и лечении иммуновоспалительных
ревматических заболеваний (ИВРЗ), приведшие к существенному улучшению прогноза …

Venetoclax is a B cell lymphoma 2 (BCL-2)–selective antagonist used to treat chronic
lymphocytic leukemia (CLL) and acute myelogenous leukemia (AML). Although this has …

The discovery of JAKs and STATs and their roles in cytokine and IFN action represented a
significant basic advance and a new paradigm in cell signaling. This was quickly followed by …

Abstract The Janus kinases or JAKs are a family of intracellular tyrosine kinases that play an
essential role in the signaling of numerous cytokines that have been implicated in the …

Systemic autoimmune disorders are complex heterogeneous chronic diseases involving
many different immune cells. A significant proportion of patients respond poorly to therapy. In …

Janus kinases (JAKs) are the non-receptor tyrosine kinases covering JAK1, JAK2, JAK3,
and TYK2 which regulate signal transductions of hematopoietic cytokines and growth factors …