[HTML][HTML] Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson's Disease

SG Kim, JS Hwang, NP George, YE Jang… - International Journal of …, 2024 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
loss of dopaminergic neurons in the substantia nigra. Recent studies have highlighted the …

Integrative approach of omics and imaging data to discover new insights for understanding brain diseases

JH Yoon, H Lee, D Kwon, D Lee, S Lee… - Brain …, 2024 - academic.oup.com
Treatments that can completely resolve brain diseases have yet to be discovered. Omics is a
novel technology that allows researchers to understand the molecular pathways underlying …

[HTML][HTML] Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses

A Khalafiyan, M Fadaie, F Khara, A Zarrabi… - Drug Discovery …, 2024 - Elsevier
Autophagy, the lysosome-driven breakdown of intracellular components, is pivotal in
regulating eukaryotic cellular processes and maintaining homeostasis, making it …

The axes of biology: a novel axes-based network embedding paradigm to decipher the functional mechanisms of the cell

S Doria-Belenguer, A Xenos, G Ceddia… - Bioinformatics …, 2024 - academic.oup.com
Common approaches for deciphering biological networks involve network embedding
algorithms. These approaches strictly focus on clustering the genes' embedding vectors and …

Bridging the gap in precision medicine: TranSYS training programme for next-generation scientists

L Andreoli, C Berca, S Katz, M Korshevniuk… - Frontiers in …, 2024 - frontiersin.org
Introduction In the evolving healthcare landscape, precision medicine's rise necessitates
adaptable doctoral training. The European Union has recognized this and promotes the …

How quantum computing can enhance biomarker discovery for multi-factorial diseases

FF Flöther, D Blankenberg, M Demidik… - arXiv preprint arXiv …, 2024 - arxiv.org
Biomarkers play a central role in medicine's gradual progress towards proactive,
personalized precision diagnostics and interventions. However, finding biomarkers that …

MONFIT: multi-omics factorization-based integration of time-series data sheds light on Parkinson's disease

K Mihajlović, N Malod-Dognin, C Ameli… - NAR Molecular …, 2024 - academic.oup.com
Parkinson's disease (PD) is a severe and complex multifactorial neurodegenerative disease
with still elusive pathophysiology preventing the development of curative treatments …