Objective To create a treatment algorithm for focal grade 3 or 4 cartilage defects of the knee
using both classic and novel cartilage restoration techniques. Design A comprehensive …

Purpose To systematically review randomized controlled trials to compare clinical outcomes
of microfracture (MFx) versus third-generation autologous chondrocyte implantation (ACI) for …

Focal cartilage injuries have poor intrinsic healing potential and often progress to
osteoarthritis, a costly disease affecting almost a third of adults in the United States. To treat …

Although regenerative medicine products are at the forefront of scientific research,
technological innovation, and clinical translation, their reproducibility and large-scale …

Background: Microfracture (MFx) is one of the most common techniques used for the
treatment of articular cartilage defects, although recently there has been a trend toward the …

Articular cartilage defects caused by injury frequently lead to osteoarthritis, a painful and
costly disease. Despite widely used surgical methods to treat articular cartilage defects and …

Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and
the application in tissue engineering. Also, the application of subpopulations of MSCs in …

The development of induced pluripotent stem cells has brought unlimited possibilities to the
field of regenerative medicine. This could be ideal for treating osteoarthritis and other …

The poor intrinsic healing properties of cartilage result in the frequent development of
osteoarthritis and chronic tissue degeneration following injury. Articular cartilage tissue …

Cell sheet tissue engineering requires prolonged in vitro culture for the development of
implantable devices. Unfortunately, lengthy in vitro culture is associated with cell phenotype …