Oxidative phosphorylation provides most of the ATP that higher animals and plants use to
support life and is responsible for setting and maintaining metabolic homeostasis. The …

It has been 60 yr since the discovery of reactive oxygen species (ROS) in biology and the
beginning of the scientific community's attempt to understand the impact of the unpaired …

We review the substantial recent progress made in understanding the underlying
mechanisms controlling breathing and the applicability of these findings to selected human …

The mammalian airways are sensitive to inhaled stimuli, and airway diseases are
characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents …

Obstructive sleep apnea (OSA) and hypertension are closely linked conditions. Disordered
breathing events in OSA are characterized by increasing efforts against an occluded airway …

Mammalian carotid bodies are the main peripheral arterial chemoreceptors, strategically
located at the bifurcation of the common carotid artery. When stimulated these receptors …

There are numerous mechanisms by which mammals respond to hypoxia. These include
acute changes in pulmonary arterial tone due to smooth muscle cell contraction, acute …

Mammalian carotid bodies are richly vascularized chemosensory organs that sense blood
levels of O2, CO2/H+, and glucose and maintain homeostatic regulation of these levels via …

Reduced mitochondrial oxidative phosphorylation, via activation of adenylate kinase and the
resulting exponential rise in the cellular AMP/ATP ratio, appears to be a critical factor …

Background The use of anesthetics may result in depression of the hypoxic ventilatory
response. Since there are no receptor-specific antagonists for most anesthetics, there is the …