Ki-67 protein has been widely used as a proliferation marker for human tumor cells for
decades. In recent studies, multiple molecular functions of this large protein have become …

Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

Breast cancer is the most frequently diagnosed cancer in women and one of the leading
causes of cancer death for women. Worldwide, over 1.3 million cases of invasive breast …

The epithelial–mesenchymal transition (EMT) has recently been linked to stem cell
phenotype,. However, the molecular mechanism underlying EMT and regulation of …

In about half of all human cancers, the tumor suppressor p53 protein is either lost or
mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

The fallopian tube is now generally considered the dominant site of origin for high-grade
serous ovarian carcinoma. However, the molecular pathogenesis of fallopian tube-derived …

It is acknowledged that cancer cells are able to undergo senescence in response to
clinically used chemotherapeutics. Moreover, recent years have provided evidence that …