Mechanisms of cancer cell death induction by paclitaxel: an updated review

S Zhao, Y Tang, R Wang, M Najafi - Apoptosis, 2022 - Springer
Chemoresistance of cancer cells is a major problem in treating cancer. Knowledge of how
cancer cells may die or resist cancer drugs is critical to providing certain strategies to …

BCS class IV drugs: Highly notorious candidates for formulation development

R Ghadi, N Dand - Journal of Controlled Release, 2017 - Elsevier
BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …

Milk-derived exosomes for oral delivery of paclitaxel

AK Agrawal, F Aqil, J Jeyabalan, WA Spencer… - … , Biology and Medicine, 2017 - Elsevier
In this report milk-derived exosomes have been investigated for oral delivery of the
chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional iv therapy for …

Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems

JC Kraft, JP Freeling, Z Wang, RJY Ho - Journal of pharmaceutical …, 2014 - Elsevier
Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid
nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The …

Current approaches in lipid-based nanocarriers for oral drug delivery

M Plaza-Oliver, MJ Santander-Ortega… - Drug Delivery and …, 2021 - Springer
Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral
bioavailability because of their remarkable advantages like low toxicity, affordable scale-up …

Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

Y Lu, K Park - International journal of pharmaceutics, 2013 - Elsevier
Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in
the clinical setting. Due to the rising number of compounds having solubility issues, finding …

Oral delivery of anticancer drugs: challenges and opportunities

K Thanki, RP Gangwal, AT Sangamwar… - Journal of controlled …, 2013 - Elsevier
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

Coexistence of passive and carrier-mediated processes in drug transport

K Sugano, M Kansy, P Artursson, A Avdeef… - Nature reviews Drug …, 2010 - nature.com
The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

Pharmaceutical nanotechnology for oral delivery of anticancer drugs

L Mei, Z Zhang, L Zhao, L Huang, XL Yang… - Advanced drug delivery …, 2013 - Elsevier
Oral chemotherapy is an important topic in the 21st century medicine, which may radically
change the current regimen of chemotherapy and greatly improve the quality of life of the …

Lipid nanocapsules: a new platform for nanomedicine

NT Huynh, C Passirani, P Saulnier, JP Benoît - International journal of …, 2009 - Elsevier
Nanomedicine, an emerging new field created by the fusion of nanotechnology and
medicine, is one of the most promising pathways for the development of effective targeted …