Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia

B García-Bueno, P Gassó, KS MacDowell… - Journal of Psychiatry and …, 2016 - jpn.ca
Background: Alterations in the innate immune/inflammatory system may underlie the
pathophysiology of schizophrenia, but we do not understand the mechanisms involved. The …

Identifying Plasma Biomarkers with high specificity for major depressive disorder: a multi-level proteomics study

Y Shi, R Song, L Wang, Y Qi, H Zhang, J Zhu… - Journal of affective …, 2020 - Elsevier
Background There are currently no objective diagnostic biomarkers for major depressive
disorder (MDD) due to the biological complexity of the disorder. The existence of blood …

Network-based analysis of schizophrenia genome-wide association data to detect the joint functional association signals

S Chang, K Fang, K Zhang, J Wang - PLoS One, 2015 - journals.plos.org
Schizophrenia is a common psychiatric disorder with high heritability and complex genetic
architecture. Genome-wide association studies (GWAS) have identified several significant …

A powerful conditional gene-based association approach implicated functionally important genes for schizophrenia

M Li, L Jiang, TSH Mak, JSH Kwan, C Xue… - …, 2019 - academic.oup.com
Motivation It remains challenging to unravel new susceptibility genes of complex diseases
and the mechanisms in genome-wide association studies. There are at least two difficulties …

Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients

M Li, L Shen, L Chen, C Huai, H Huang, X Wu… - Translational …, 2020 - nature.com
Schizophrenia (SCZ) is a highly heritable psychiatric disorder that affects approximately 1%
of population around the world. However, early relevant studies did not reach clear …

The role of genes and environment on brain alterations in Major Depressive Disorder: A review of twin studies: Special Section on “Translational and Neuroscience …

A Pigoni, G Delvecchio, AC Altamura, JC Soares… - Journal of Affective …, 2018 - Elsevier
Background Although it has been consistently reported the important role of genetic and
environmental risk factors on structural and functional alterations in Major Depressive …

Disease-discordant twin structural MRI studies on affective disorders

G Delvecchio, A Pigoni, IE Bauer, JC Soares… - Neuroscience & …, 2020 - Elsevier
Magnetic resonance imaging (MRI) studies have identified neural structures implicated in
the pathophysiology of mood disorders, especially bipolar disorder (BD) and major …

Exploration of potential biomarkers for early bladder cancer based on urine proteomics

X Zhou, F Xue, T Li, J Xue, S Yue, S Zhao, H Lu… - Frontiers in …, 2024 - frontiersin.org
Background Bladder cancer is a common malignant tumor of the urinary system. The
progression of the condition is associated with a poor prognosis, so it is necessary to identify …

Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia

Y Tao, R Zhao, B Yang, J Han, Y Li - Journal of Translational Medicine, 2024 - Springer
Background Numerous studies highlight the genetic underpinnings of mental disorders
comorbidity, particularly in anxiety, depression, and schizophrenia. However, their shared …

Serum proteomics analysis of drug-naïve patients with generalised anxiety disorder: Tandem mass tags and multiple reaction monitoring

X Li, S Zheng, Z Feng, X Liu, Y Ding… - The World Journal of …, 2024 - Taylor & Francis
Objectives The prevalence of generalised anxiety disorder (GAD) is high. However, the
underlying mechanisms remain elusive. Proteomics techniques can be employed to assess …