The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

The functional versatility of Wnt/β-catenin signaling can be seen by its ability to act in stem
cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis …

Wnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of Wnt
reporter transgenes, β-catenin's dual roles in adhesion and signaling, and hair follicle …

The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many
studies have reported that tumor progression and metastasis increase by MSCs. In contrast …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Animal models of cancer have been instrumental in advancing our understanding of the
biology of tumor initiation and progression, in studying gene function and in performing …

The mammary gland is a unique organ with the ability to undergo repeated cyclic changes
throughout the life of mammals. Among domesticated livestock species, ruminants (cattle …

Simple Summary Triple negative breast cancer lacks targeted therapies and has poor
prognosis; chemotherapy is currently the main treatment modality. Growing evidence has …