Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …

Neurodegenerative diseases (NDs) are characterised by progressive dysfunction of
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …

Heterozygous gain-of-kinase function variants in LRRK2 (leucine-rich repeat kinase 2)
cause 1–2% of all cases of Parkinson's disease (PD) albeit with incomplete and age …

Background Mutations in LRRK2 are the most common cause of autosomal dominant
Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is …

The Parkinson's disease (PD)-associated kinase Leucine-Rich Repeat Kinase 2 (LRRK2) is
a crucial modulator of the autophagy-lysosome pathway, but unclarity exists on the precise …

Parkinson's disease (PD) is a multi-stage neurodegenerative disorder with largely unknown
etiology. Recent findings have identified PD-associated autoimmune features including …

Mutations of the human leucine-rich repeat kinase 2 (LRRK2) have been associated with
both, idiopathic and familial Parkinson's disease (PD). Most of these pathogenic mutations …

Despite several advances in the field, pharmacodynamic outcome measures reflective of
LRRK2 kinase activity in clinical biofluids remain urgently needed. A variety of targets and …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are one of the most common causes of
familial Parkinson's disease (PD). The most common mutations in the LRRK2 gene induce …

Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein share enigmatic roles in the
pathobiology of Parkinson's disease (PD). LRRK2 mutations are a common genetic cause of …