Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Cell-derived extracellular matrices (CD-ECMs) captured increasing attention since the first
studies in the 1980s. The biological resemblance of CD-ECMs to their in vivo counterparts …

Corneal transplantation is an important surgical treatment for many common corneal
diseases. However, a worldwide shortage of tissue from suitable corneal donors has meant …

In vivo, the interior and exterior of cells is populated by various macromolecules that create
an extremely crowded milieu. Yet again, in vitro eukaryotic cell culture is conducted in dilute …

Opportunities for exploiting the inherent value of protein-rich meat processing co-products,
in the context of increased global demand for protein and for sustainable processing …

Collagen type I is the most abundant extracellular matrix protein, and collagen type I
supramolecular assemblies (eg, tissue grafts, biomaterials and cell-assembled systems) are …

Cell sheet tissue engineering requires prolonged in vitro culture for the development of
implantable devices. Unfortunately, lengthy in vitro culture is associated with cell phenotype …

The cornea is an avascular, transparent tissue that is essential for visual function. Any
disturbance to the corneal transparency will result in a severe vision loss. Due to the …

In multicellular organisms, the intracellular and extracellular spaces are considerably
packed with a diverse range of macromolecular species. Yet, standard eukaryotic cell …

Scaffold-free in vitro organogenesis exploits the innate ability of cells to synthesise and
deposit their own extracellular matrix to fabricate tissue-like assemblies. Unfortunately, cell …