Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer, but resistance
is common. The initial response to platinum‑based chemotherapy is as high as 80%, but in …

Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed
by autophagosomes and degraded upon autophagosome fusion with lysosomes …

Autophagy is a lysosome-dependent, self-renewal mechanism that can degrade and recycle
cellular components in eukaryotic cells to maintain the stability of the intracellular …

The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Propolis is a natural material that honey bees (Apis mellifera) produce from various
botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and …

All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …

Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …