The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …

Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

Abstract mRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research.
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …

Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

Abstract mRNA is a versatile drug molecule with therapeutic applications ranging from
protein replacement therapies to in vivo gene engineering. mRNA delivery is often …

Ornithine transcarbamylase (OTC) plays a significant role in the urea cycle, a metabolic
pathway functioning in the liver to detoxify ammonia. OTC deficiency (OTCD) is the most …

Messenger RNA (mRNA) is an emerging class of biotherapeutics for vaccine development
and genome editing. Efficacious delivery and control of mRNA functionality selectively to …

Malignant tumors remain a primary cause of human mortality. Among the various treatment
modalities for neoplasms, tumor vaccines have consistently shown efficacy and promising …