Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Centriolar satellites comprise cytoplasmic granules that are located around the centrosome.
Their molecular identification was first reported more than a quarter of a century ago. These …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

Centriolar satellites are small electron‐dense granules that cluster in the vicinity of
centrosomes. Satellites have been implicated in multiple critical cellular functions including …

In the nervous system, cilia dysfunction perturbs the circulation of the cerebrospinal fluid,
thus affecting neurogenesis and brain homeostasis. A role for planar cell polarity (PCP) …

Centriolar satellites are small, microscopically visible granules that cluster around
centrosomes. These structures, which contain numerous proteins directly involved in …

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …

Highly conserved intraflagellar transport (IFT) protein complexes direct both the assembly of
primary cilia and the trafficking of signaling molecules. IFT complexes initially accumulate at …

Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated
by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we …

Centrioles are core structural elements of both centrosomes and cilia. Although cytoplasmic
granules called centriolar satellites have been observed around these structures, lack of a …