Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy

SD Thiberville, N Moyen, L Dupuis-Maguiraga… - Antiviral research, 2013 - Elsevier
Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …

Chikungunya virus and prospects for a vaccine

SC Weaver, JE Osorio, JA Livengood… - Expert review of …, 2012 - Taylor & Francis
In 2004, chikungunya virus (CHIKV) re-emerged from East Africa to cause devastating
epidemics of debilitating and often chronic arthralgia that have affected millions of people in …

Characterization of lethal Zika virus infection in AG129 mice

MT Aliota, EA Caine, EC Walker… - PLoS neglected …, 2016 - journals.plos.org
Background Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness
known as Zika fever, which often is accompanied by maculopapular rash, headache, and …

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

N Kose, JM Fox, G Sapparapu, R Bombardi… - Science …, 2019 - science.org
Infection with chikungunya virus (CHIKV) causes an acute illness characterized by fever,
rash, and arthralgia. However, CHIKV infection can sometimes progress to chronic arthritis …

Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses

JP Ledermann, L Guillaumot, L Yug… - PLoS neglected …, 2014 - journals.plos.org
An epidemic of Zika virus (ZIKV) illness that occurred in July 2007 on Yap Island in the
Federated States of Micronesia prompted entomological studies to identify both the primary …

Vaccine and therapeutic options to control chikungunya virus

AM Powers - Clinical microbiology reviews, 2018 - Am Soc Microbiol
Beginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …

Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

JG Julander, V Siddharthan, J Evans, R Taylor… - Antiviral research, 2017 - Elsevier
Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically
subclinical, severe neurologic manifestations in fetuses and newborns after congenital …

Tropism of the chikungunya virus

G Matusali, F Colavita, L Bordi, E Lalle, G Ippolito… - Viruses, 2019 - mdpi.com
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus that displays a large cell
and organ tropism, and causes a broad range of clinical symptoms in humans. It is …

Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein

R Gorchakov, E Wang, G Leal, NL Forrester… - Journal of …, 2012 - Am Soc Microbiol
Chikungunya virus (CHIKV) is the mosquito-borne alphavirus that is the etiologic agent of
massive outbreaks of arthralgic febrile illness that recently affected millions of people in …

Chikungunya virus pathogenesis: From bedside to bench

T Couderc, M Lecuit - Antiviral research, 2015 - Elsevier
Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A
decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then …