▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …

Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed,
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …

Antibody-based targeted immunotherapy has shown promise as an approach to treat
cancer. However, many known tumor-associated antigens are not expressed as integral …

Reliable predictions of immunogenic peptides are essential in rational vaccine design and
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …

Publisher Summary This chapter reviews the generation and TAP-mediated transport of
peptides for major histocompatibility complex class I molecules. The translocation of …

Skeletal muscle differentiation entails the coordination of muscle-specific gene expression
and terminal withdrawal from the cell cycle. This cell cycle arrest in the G0 phase requires …

Assembly of MHC class I–β 2 microglobulin (β 2 m) dimers in the endoplasmic reticulum
involves two chaperones. Calnexin has previously been shown to interact with free class I …

CD8+ T‐cell responses are critical in the immunological control of tumours and infectious
diseases. To prime CD8+ T cells against these cell‐associated antigens, exogenous …

Background: The human carcinoembryonic antigen (CEA), which is expressed in several
cancer types, is a potential target for specific immunotherapy using recombinant vaccines …

Tumor-specific CD8+ T cells can potentially be activated by two distinct mechanisms of
major histocompatibility complex class I–restricted antigen presentation as follows: direct …