Background Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed
to estimate the association of treatment success and death with the use of individual drugs …

This systematic review aimed to update the current evidence for multidrug-resistant
tuberculosis (MDR-TB) treatment. We searched for studies that reported treatment …

Rationale: Acquired resistance is an important driver of multidrug-resistant tuberculosis (TB),
even with good treatment adherence. However, exactly what initiates the resistance and …

Background Levofloxacin is used for the treatment of multidrug-resistant tuberculosis;
however the optimal dose is unknown. Methods We used the hollow fiber system model of …

We sought to compare the effectiveness of two World Health Organization (WHO)-
recommended regimens for the treatment of rifampin-or multidrug-resistant (RR/MDR) …

Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of
extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium …

Background Little is known about the impact of drug-resistance on clinical outcomes among
patients with tuberculosis meningitis (TBM). Methods A retrospective cohort study among …

Little is known about the impact of comorbidities on multidrug resistant (MDR) and
extensively drug resistant (XDR) tuberculosis (TB) treatment outcomes. We aimed to …

Background The emergence of pre-extensively and extensively drug-resistant tuberculosis
(Pre-XDR/XDR-TB) is the major hurdle for TB prevention and care programs especially in …

Objectives We aimed to evaluate the effect of undernutrition on sputum culture conversion
and treatment outcomes among people with multidrug-resistant tuberculosis (MDR-TB) …