Ecology and evolution of Mycobacterium tuberculosis
S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …
The causative agents of TB are a group of closely related bacteria known as the …
Tuberculosis treatment monitoring and outcome measures: new interest and new strategies
J Heyckendorf, SB Georghiou, N Frahm… - Clinical microbiology …, 2022 - Am Soc Microbiol
Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …
global public health threat. A significant challenge for TB control efforts has been the …
[HTML][HTML] A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
JCS Ngabonziza, C Loiseau, M Marceau… - Nature …, 2020 - nature.com
The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …
Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis
Although progress has been made to reduce global incidence of drug-susceptible
tuberculosis, the emergence of multidrug-resistant (MDR) and extensively drug-resistant …
tuberculosis, the emergence of multidrug-resistant (MDR) and extensively drug-resistant …
Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes
Epidemics of drug-resistant bacteria emerge worldwide, even as resistant strains frequently
have reduced fitness compared to their drug-susceptible counterparts. Data from model …
have reduced fitness compared to their drug-susceptible counterparts. Data from model …
[HTML][HTML] Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in
individual hosts for decades. We sequenced the genomes of 21 strains representative of the …
individual hosts for decades. We sequenced the genomes of 21 strains representative of the …
Host–pathogen coevolution in human tuberculosis
S Gagneux - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Tuberculosis (TB) is a disease of antiquity. Yet TB today still causes more adult deaths than
any other single infectious disease. Recent studies show that contrary to the common view …
any other single infectious disease. Recent studies show that contrary to the common view …
[HTML][HTML] Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population …
K Brudey, JR Driscoll, L Rigouts, WM Prodinger… - BMC microbiology, 2006 - Springer
Abstract Background The Direct Repeat locus of the Mycobacterium tuberculosis complex
(MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic …
(MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic …
[HTML][HTML] Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis
The highly successful human pathogen Mycobacterium tuberculosis has an extremely low
level of genetic variation, which suggests that the entire population resulted from clonal …
level of genetic variation, which suggests that the entire population resulted from clonal …
[HTML][HTML] Genomic insights into tuberculosis
JE Galagan - Nature Reviews Genetics, 2014 - nature.com
Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …