The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …

Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of
treatment options. Aggressive CRC remains difficult to treat owing to the activation of …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

Neural stem cells from neurogenic regions of mammalian CNS are clonogenic in an in vitro
culture system exploiting serum and anchorage withdrawal in medium supplemented with …

Development makes reiterative use of a surprisingly small set of essential molecular signals:
the Wingless (Wg/Wnt), Hedgehog (Hh), Transforming Growth Factor-(TGF-), Receptor …

Introduction Notch signaling has been implicated in the regulation of cell-fate decisions such
as self-renewal of adult stem cells and differentiation of progenitor cells along a particular …

To account for the complex genetics, the developmental biology, and the late
adolescent/early adulthood onset of schizophrenia, the “two-hit” hypothesis has gained …

The Notch family of proteins plays an integral role in determining cell fates, such as
proliferation, differentiation, and apoptosis. We show that Notch-1 and its ligands, Delta-like …

The Notch signaling pathway maintains a balance between cell proliferation and apoptosis,
and thus it is believed that Notch signaling pathway may play an important role in the …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …