Hemoglobinopathies are the most common single gene disorders (monogenic disorders) in
the world population. Due to specific position of Iran and the presence of multi-ethnic groups …

Abstract Alpha-thalassemia (α-thal) is probably the most prevalent monogenic condition in
the world. Deletions are the most common types of mutations in α-thal, followed by point …

Alpha thalassemia is the most prevalent monogenic gene disorder in the world, especially in
Mediterranean countries. In the current hematological phenotype of patients with different …

Context Thalassaemia is one of the most common inherited autosomal recessive disorders
around the world. A considerable amount of literature has been published about the type of …

Background Despite the significant advances in thalassemia pathobiology and efficacy of
chelation regimens, complications of transfusion therapy have attenuated the reproductive …

Background: Hemoglobinopathies are inherited blood disorders with an autosomal
recessive pattern. We aimed to evaluate the frequency of mutations of thalassemia and …

Background Thalassemia major is one of the most common hereditary disorders, and it
causes ineffective hematopoiesis in the body through disarrangement of the hemoglobin …

ABSTRACT Background and Objectives: Hemoglobinopathies are characterized by defects
in the synthesis of globin chains of hemoglobin (Hb). The purpose of the present study was …

Objective To date, more than 400 alpha chain variants or point mutations in the α-globin
genes that lead to single amino acid substitutions have been described. Here, we state a …

Abstract α-Thalassemia (α-thal) is a common hemoglobinopathy mainly caused by deletion
of one or both α-globin genes. We describe an autochthonous Belgian family diagnosed …