The pulmonary circulation is a low-pressure, low-resistance circuit whose primary function is
to deliver deoxygenated blood to, and oxygenated blood from, the pulmonary capillary bed …

Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …

Background—Conventional cardiopulmonary exercise testing can objectively measure
exercise intolerance but cannot provide comprehensive evaluation of physiology. This …

Inhalation of e-cigarette's aerosols (vaping) has the potential to disrupt pulmonary gas
exchange, but the effects in asymptomatic users are unknown. We assessed ventilation …

This article provides an overview of the journey of inspired oxygen after its uptake across the
alveolar–capillary interface, and the interplay among tissue perfusion, diffusion, and cellular …

Patients with mild chronic obstructive pulmonary disease (COPD) demonstrate resting
pulmonary vascular dysfunction as well as a blunted pulmonary diffusing capacity (DLCO) …

High-altitude pulmonary edema (HAPE) is a potentially fatal condition affecting high-altitude
sojourners. The biggest predictor of HAPE development is a history of prior HAPE. Magnetic …

Key points The distribution of pulmonary perfusion is affected by gravity, vascular branching
structure and active regulatory mechanisms, which may be disrupted by cardiopulmonary …

This chapter is devoted to understanding the principles that underlie pulmonary gas
exchange, the factors that impair pulmonary gas exchange, how those factors serve to limit …

Specific ventilation imaging (SVI) is a functional magnetic resonance imaging technique
capable of quantifying specific ventilation―the ratio of the fresh gas entering a lung region …