CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
[PDF][PDF] Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity
T cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based
vaccine candidate, composed of SARS-CoV-2 T cell epitopes derived from various viral …
vaccine candidate, composed of SARS-CoV-2 T cell epitopes derived from various viral …
[HTML][HTML] SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …
but also for the development of vaccines, identification of exact viral T cell epitopes is …
[HTML][HTML] Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
G Hütter, D Nowak, M Mossner… - … England Journal of …, 2009 - Mass Medical Soc
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a
CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5) …
CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5) …
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity
M Rosás-Umbert, JD Gunst, MH Pahus… - Nature …, 2022 - nature.com
In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
[HTML][HTML] Magnitude and kinetics of CD8+ T cell activation during hyperacute HIV infection impact viral set point
ZM Ndhlovu, P Kamya, N Mewalal, HN Kløverpris… - Immunity, 2015 - cell.com
CD8+ T cells contribute to the control of HIV, but it is not clear whether initial immune
responses modulate the viral set point. We screened high-risk uninfected women twice a …
responses modulate the viral set point. We screened high-risk uninfected women twice a …
[HTML][HTML] Restriction factors: from intrinsic viral restriction to shaping cellular immunity against HIV-1
M Colomer-Lluch, A Ruiz, A Moris… - Frontiers in …, 2018 - frontiersin.org
Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …
blocking viral replication and propagation. In addition to interfering at critical steps of the …
Influence of HLA-C expression level on HIV control
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant
genome-wide effect on HIV control in European Americans and is also associated with the …
genome-wide effect on HIV control in European Americans and is also associated with the …
[PDF][PDF] Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy
Chronic viral infections can appear in two very different forms: those that are typically
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …