Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

Cellular senescence contributes to age-related disorders including physical dysfunction,
disabilities, and mortality caused by tissue inflammation and damage. Senescent cells …

Senescent cells accumulate with age in vertebrates and promote aging largely through their
senescence‐associated secretory phenotype (SASP). Many types of stress induce …

Cellular senescence is defined as irreversible cell cycle arrest caused by various processes
that render viable cells non-functional, hampering normal tissue homeostasis. It has many …

The ongoing pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
causes a disproportionate number of severe cases and deaths in older adults. Severe SARS …

Musculoskeletal aging encompasses the decline in bone and muscle function, leading to
conditions such as frailty, osteoporosis, and sarcopenia. Unraveling the underlying …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …