Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals
and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon …

The intestinal epithelial monolayer constitutes a physical and functional barrier between the
organism and the external environment. It regulates nutrients absorption, water and ion …

Combination therapy is an emerging strategy that is under intensive preclinical investigation
for the treatment of various diseases. CD98 is highly overexpressed on the surfaces of …

Background The gut microflora in some patients with Crohn's disease can be reduced in
numbers of butyrate-producing bacteria and this could result in metabolic stress in the …

Epithelial permeability is often increased in inflammatory bowel diseases. We hypothesized
that perturbed mitochondrial function would cause barrier dysfunction and hence epithelial …

Exposure to stressful stimuli results in the activation of multiple physiological processes
aimed at maintaining homeostasis within the body. These physiological processes also …

Diseases of mucosal inflammation represent important causes of morbidity and mortality,
and have led to Intense research efforts to understand the factors that lead to their …

Background & Aims Mitochondria exist in a constantly remodelling network, and excessive
fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric …

Although the incidence of Crohn's disease (CD) in China is not as high as that in European
and American countries, there has been a clear increasing trend in recent years. Little is …

Background & Aims Dysregulated energy homeostasis in the intestinal mucosa frequently is
observed in patients with ulcerative colitis (UC). Intestinal tissues from these patients have …