Frontotemporal dementia is an umbrella clinical term that encompasses a group of
neurodegenerative diseases characterised by progressive deficits in behaviour, executive …

Despite advances towards understanding the molecular pathophysiology of the
neurodegenerative dementias, the mechanisms linking molecular changes to …

The heterogeneity of neurodegenerative diseases is a key confound to disease
understanding and treatment development, as study cohorts typically include multiple …

Objective To characterize in vivo signatures of pathological diagnosis in a large cohort of
patients with primary progressive aphasia (PPA) variants defined by current diagnostic …

Accurately predicting the underlying neuropathological diagnosis in patients with
behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for …

Fifty-eight autopsies of patients with primary progressive aphasia are reported. Twenty-three
of these were previously described (Mesulam et al., 2008) but had their neuropathological …

A major recent discovery was the identification of an expansion of a non-coding GGGGCC
hexanucleotide repeat in the C9ORF72 gene in patients with frontotemporal dementia and …

Abstract Development of therapeutics for genetically complex neurodegenerative diseases
such as sporadic amyotrophic lateral sclerosis (ALS) has largely been hampered by lack of …

Relating clinical symptoms to neuroanatomical profiles of brain damage and ultimately to
tissue pathology is a key challenge in the field of neurodegenerative disease and …

Frontotemporal dementia (FTD) is a focal clinical syndrome characterised by profound
changes in personality and social conduct and associated with circumscribed degeneration …