The pyrimidine scaffold is present in many bioactive drugs; therefore, efficient synthetic
routes that provide shorter reaction times, higher yields, and site-selective reactions are …

The simple preparation and functionalization of oxa/aza heterocycles requires new and
efficient starting materials to be discovered so that regioselective methodologies with a wide …

Fluorinated lithium β-diketonates bearing a methyl acetal group behave in the condensation
reactions with hydrazines as trielectrophilic building blocks for the preparation of pyrazoles …

A systematized survey of reviews and monographs published in 2021 on all aspects of
heterocyclic chemistry is given. Methods for the synthesis, reactivity, and practically useful …

α-Azido ketones and their vinylogous relatives β-alkoxy-γ-azido enones are versatile
building blocks for constructing diverse heterocyclic products, but are prone to azide …

This study reports two strategies for preparing O-alkyl derivatives of 6-substituted-4-
(trifluoromethyl) pyrimidin-(1 H)-ones: a linear protocol of alkylation, using a CCC-building …

The selective N-or O-alkylation of 4-(trihalomethyl) pyrimidin-2 (1 H)-ones, using 5-bromo
enones/enaminones as alkylating agents, is reported. It was found that the selectivity toward …

This study details the chemo-and regioselective synthesis and spectroscopic and thermal
analysis characterization of trifluoromethyl bipyrazoles and polypyrazoles by stepwise N …

An efficient, one‐pot, protecting‐group‐free, and regioselective protocol to obtain
enantiomerically pure (Z)‐5‐methylene‐containing morpholin‐2‐ones, using α‐amino acids …

An approach was developed for the synthesis of polyfunctionalized pyrimidines based on
analogs of 1, 2, 4-triketones. Acetal-substituted β-diketones are involved in the condensation …