Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
[HTML][HTML] Molecular dynamics simulation for all
SA Hollingsworth, RO Dror - Neuron, 2018 - cell.com
The impact of molecular dynamics (MD) simulations in molecular biology and drug discovery
has expanded dramatically in recent years. These simulations capture the behavior of …
has expanded dramatically in recent years. These simulations capture the behavior of …
[HTML][HTML] Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …
glutamate receptors mediate fast excitatory neurotransmission throughout the central …
Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM
Glutamate-gated AMPA receptors mediate the fast component of excitatory signal
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
transduction at chemical synapses throughout all regions of the mammalian brain. AMPA …
[HTML][HTML] AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations
of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role …
of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role …
[HTML][HTML] Opening of glutamate receptor channel to subconductance levels
MV Yelshanskaya, DS Patel, CM Kottke, MG Kurnikova… - Nature, 2022 - nature.com
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open
their pores in response to binding of the agonist glutamate,–. An ionic current through a …
their pores in response to binding of the agonist glutamate,–. An ionic current through a …
[HTML][HTML] Functional organization of postsynaptic glutamate receptors
N Scheefhals, HD MacGillavry - Molecular and Cellular Neuroscience, 2018 - Elsevier
Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …
[HTML][HTML] Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
SP Gangwar, LY Yen, MV Yelshanskaya… - Nature Structural & …, 2023 - nature.com
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
[HTML][HTML] AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
J Díaz-Alonso, RA Nicoll - Neuropharmacology, 2021 - Elsevier
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …