Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …

Hydrogels that provide mechanical support and sustainably release therapeutics have been
used to treat tendon injuries. However, most hydrogels are insufficiently tough, release …

Objectives The incidence of acute Achilles tendon rupture appears to be increasing. The aim
of this study was to summarize various therapies for acute Achilles tendon rupture and …

Effective countermeasures for tendon injury remains unsatisfactory. Mesenchymal stem cell-
derived extracellular vesicles (MSC-EVs)-based therapy via regulation of Mφ-mediated …

Background: Early functional rehabilitation is frequently discussed in treating Achilles
tendon rupture. A consistent definition of what constitutes early functional rehabilitation has …

The extracellular matrix (ECM) is the primary biomechanical environment that interacts with
tendon cells (tenocytes). Stresses applied via muscle contraction during skeletal movement …

Aging is the largest risk factor for Achilles tendon associated disorders and rupture. Although
Achilles tendon macroscale elastic properties are suggested to decline with aging, less is …

Tendon and ligament injuries are the most common musculoskeletal injuries, which not only
impact the quality of life but result in a massive economic burden. Surgical interventions for …

Spontaneous rupture of the Achilles tendon is increasingly common in the middle aged
population. However, the cause for the particularly high incidence of injury in this age group …

The Achilles tendon is the most commonly ruptured tendon in the human body. Numerous
studies have reported incidence of these injuries to be upwards of five times as common in …