Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
Gene body methylation in cancer: molecular mechanisms and clinical applications
Q Wang, F Xiong, G Wu, W Liu, J Chen, B Wang… - Clinical …, 2022 - Springer
DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
Decoding the function of bivalent chromatin in development and cancer
Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …
H3K27me3, histone modifications generally associated with transcriptionally active and …
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2
play an essential role in gene regulation, cellular differentiation, and development. However …
play an essential role in gene regulation, cellular differentiation, and development. However …
[HTML][HTML] Understanding the relationship between DNA methylation and histone lysine methylation
DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …
become clear that the DNA and histone lysine methylation systems are highly interrelated …
Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma
E Hervouet, P Peixoto, R Delage-Mourroux… - Clinical …, 2018 - Springer
Our current view of DNA methylation processes is strongly moving: First, even if it was
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
generally admitted that DNMT3A and DNMT3B are associated with de novo methylation and …
Epigenetic mechanisms in inflammation
D Bayarsaihan - Journal of dental research, 2011 - journals.sagepub.com
Epigenetic modifications occur in response to environmental changes and play a
fundamental role in gene expression following environmental stimuli. Major epigenetic …
fundamental role in gene expression following environmental stimuli. Major epigenetic …
[HTML][HTML] Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …
specific gene expression programs during multicellular development. In addition to …
Impact of DNA methylation on 3D genome structure
D Buitrago, M Labrador, JP Arcon, R Lema… - Nature …, 2021 - nature.com
Determining the effect of DNA methylation on chromatin structure and function in higher
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …