The transcription factor NRF2 coordinates the expression of a vast array of cytoprotective
and metabolic genes in response to various stress inputs to restore cellular homeostasis …

Ovarian cancer is one of the most dangerous gynecologic malignancies showing a high
fatality rate because of late diagnosis and relapse occurrence due to chemoresistance …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

Drug resistance is a major challenge in cancer treatment. The substrates of NAD (P) H:
quinone oxidoreductase 1 (NQO1) show a promising anticancer effect in clinical trials. We …

Natural products that contain ortho-quinones show great potential as anticancer agents but
have been largely discarded from clinical development because their redox-cycling …

Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Head and neck cancer is a highly genetic and metabolic heterogeneous collection of
malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses …

Bioenergetic perturbations driving neoplastic growth increase the production of reactive
oxygen species (ROS), requiring a compensatory increase in ROS scavengers to limit …

Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and
extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not …